#6698 THROMBOPROPHYLAXIS IN PEDIATRIC KIDNEY TRANSPLANTATION: A META-ANALYSIS

Abstract Background and Aims Kidney transplant patients are at higher risk for developing renal graft thrombosis, especially in pediatric patients. Renal thrombosis mainly causes failure leading to high morbidity, mortality, a significant impact on quality of life. To minimize the antithrombotic prophylaxis is widely used. However, effect kidney transplantation still matter discussion. Therefore, we carried out meta-analytic synthesis determine Method We systematically searched MEDLINE, CENTRAL (Cochrane Central Register Controlled Trials), Web Science. The eligible studies were identifying incidence hemorrhagic complication (bleeding bleeding severity), adverse outcomes related compared with control group (placebo, active treatment, no prophylaxis). Meta-analysis was using Review Manager 5.3. random-effects model used compute pooled estimates ratio (RR) 95% confidence intervals (CI). Results A total seven 10,51 included synthesis. Heparin across all as preferred prophylaxis. from meta-analysis reported that overall significantly lower (RR = 0.81, CI 0.06-0.56, p 0.003). There difference found complications between 0.43-1.54). Similarly, there deaths 0.33, 0.01-22.45) Conclusion results showed reduced transplantation. due limited outcomes, further real-world long-term follow-up required generate sufficient data use